4x4 card question

Can a 4x4 mic/line input output card be used with the “slave” output card removed? How will CSD recognize this card and will it allow the remaining open slots to be populated?

This question arises because we have a system in the field fully populated with 4x4 cards that we’ve recently upgraded with an ESPlink card. We no longer need the analog outputs and we require more inputs for the system.